Virgin Atlantic is expected to ask for a government bailout worth hundreds of millions of pounds in the coming days, the BBC understands.
Requests for state aid are also expected from other airlines.
The Government has said it will only step in to help struggling airlines “as a last resort” and on a case-by-case basis.
UK-based airlines have already announced measures to save money such as temporarily laying-off staff.
Virgin Atlantic had previously suggested the Government offer UK carriers £7.5 billion in credit facilities.
The vast bulk of flights to and from the UK have been grounded amid the coronavirus pandemic.
Some airlines like British Airways are still operating a number of rescue flights to bring stranded Brits home.
The US Senate on Wednesday passed a $58 billion (£46.6 billion) aid package for its airline industry, which included cash for paying pilot, crew and staff salaries.